http://ajhp.online/index.php/journal/issue/feed Asian Journal of Hospital Pharmacy 2022-10-15T13:23:26-05:00 Dr. G. V. Nagaraju editor@ajhp.online Open Journal Systems <p><strong>Asian Journal of Hospital Pharmacy (<em>Asian Jour Hosp Phar</em>)</strong>&nbsp; &nbsp;is a double-blind Peer-Reviewed Quarterly open access international journal dedicated to the promotion of research Pharmaceutical sciences. We define Open Access journals as journals that use a funding model that does not charge readers or their institutions for access. The journal publishes Research articles, Review article, Case Reports, and Short communication from broad areas like Pharmacy practice,&nbsp; Clinical Pharmacy, Hospital Pharmacy, Pharmacotherapeutics Pharmacoepidemiology and Economics, Clinical Research, Pharmaceutics, Pharmacology, Pharmacognosy &amp; Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmaceutical Analysis,&nbsp; Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, and Biotechnology, etc.</p> <p><strong>Open Access Policy</strong></p> <p>All the Published articles By the Asian Journal of Hospital Pharmacy (AJHP) are available Worldwide Under the Open Access Policy. As per the Budapest Open Access Initiative, Readers can Directly Access Published articles without paying any subscription or access fees. Readers are allowed to read, download, copy and distribute the full text of all published articles, and readers can Utilize the published article for Non-Commercial Purpose.</p> <p><strong>Data Preservation</strong></p> <p><strong>Asian Journal of Hospital Pharmacy (AJHP)</strong>Preserved all published data content in&nbsp;PORTICO</p> http://ajhp.online/index.php/journal/article/view/54 Case study on phenylketonuria: a memic autism 2022-10-15T13:23:26-05:00 Nikhila K drnagaraju.gv@gmail.com Sahithi V drnagaraju.gv@gmail.com Yaswanth Reddy V drnagaraju.gv@gmail.com Venkata Nagaraju G drnagaraju.gv@gmail.com Manohar Babu Sitty drnagaraju.gv@gmail.com <p>Phenylketonuria (PKU) is a phenylalanine catabolism metabolic condition characterized by a decrease in the activity of the phenylalanine hydroxylase or Dihydro pteridine reductase enzyme. This inherited condition causes a build-up of phenylalanine in the bloodstream. Elevated phenylalanine levels in the blood can cause muscle rigidity, choreoathetosis, tremors, hyperreflexia, dermatitis, pale skin, and pseudo-scleroderma. The central nervous system deficiencies in PKU are caused by phenylalanine and phenyl pyruvic acid competing for dopamine, adrenaline, norepinephrine, and serotonin in the brain. Structural changes are caused by neurotransmitter inhibition and phenylalanine and phenyl pyruvic accumulations in the white matter of the posterior periventricular, frontal, and subcortical areas of the brain1. Greater myelin turnover decreased synaptogenesis, and reduced neuronal digenesis ensues from myelin deficit, resulting in cognitive development and mental retardation1. The patient in this case study is an 8-year-old boy who has been diagnosed with phenylketonuria. The patient’s parents had a history of consanguinity marriage. The patient has had seizures since he was nine months old. Speech and language delays, hearing loss, and tooth discoloration are all common symptoms. He had an MRI and a brain scan, as well as a blood amino acids test, which revealed that he has mild developmental delays. Mild to Moderate Autistic Features is Delayed.</p> 2022-10-15T00:00:00-05:00 Copyright (c) 2022